Synthetic Chemistry

SynSmart offers a vast range of synthetic chemistry services through an experienced scientific team with the aim of accelerating diverse synthetic and drug discovery needs of innovator biotech and pharmaceutical companies across the globe.
Advanced Chemistry Technologies

About the service

SynSmart offers chemistry services under flexible business arrangements including Fee for Service (FFS), Time & Material based arrangement or Full-Time Equivalent (FTE) based.

With our skills of tackling complex synthetic routes with different approaches, we endeavor for synthesizing high quality compounds at rapid speed. SynSmart works on early-stage discovery projects for pharma/ biotech customers in making intermediates, building blocks and final compounds from mg to multi-g scale.
CHEMISTRY EXPERTISE

Specialized Chemistry Capabilities

Deep synthetic expertise across diverse molecular classes and enabling technologies.
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Traditional Heterocyclic Chemistry

Synthesis of O, N, S and P heterocyclic and fused-ring analogues, Benzofuran formation, Azaindole Chemistry, Thiophene ring formation, Thiazole formation etc.

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Transition Metal-mediated Reactions

Suzuki coupling, Negishi & Heck Coupling, Buchwald-Hartwig Coupling, Phosphonate Chemistry, C-P, C-S, C-B, C-Sn and C-Si bond forming reactions, C-H activations etc.

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Difficult-to-handle and Sensitive Reagents

Including all kinds of metal-based pyrophoric reagents like lithium, magnesium and zincs, toxic reagents like metallic cyanides and metal carbonyls e.g., Reduction, Catalytic hydrogenation, Grignard, Hydroxymethylation etc.

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Handling of Gaseous Reagents

Experienced in reactions involving gases like H2, Cl2 , O2 , CO, CO2, SO3 etc. – in addition to rarer reactions like ozonolysis – even at larger scales. e.g. Chloromethylation, Bromination & Selective Reduction, all types of Halogenation

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High-temperature reactions at 290 °C
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Special Synthetic reactions

Cryogenic Reactions, Use of pyrophoric reagents, fluorinations, synthesis of fluoroalkyl and fluoro alkoxy targets, cyclopropanations, deuterations, labeling and isotope synthesis and much more.

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Nitration, Reduction and Migration

Our Chemical Synthesis Capabilities

From building blocks to complex molecules, we deliver high-quality synthetic chemistry to accelerate your discovery and development programs.

Library and Analogs

Variety of libraries ranging between focused libraries 10-100 members. Our capabilities include synthesizing libraries, synthesis of scaffolds/building blocks including complex structure involving multi-step synthesis.

Catalyst Screening

We have capabilities of synthesis and screening of different catalysts, e.g. Iridium complexes, Vanadium complexes etc.

Nucleotides

SynSmart team has the ability to synthesize a wide variety of molecules, including nucleotides and nucleosides.

Protein Degraders (PROTACs)

Chemistry of PROTACs and partial PROTACs. Our team of experienced organic chemists can tackle the synthesis of heterobifunctional target molecules used for Protein Degradation.

Asymmetric Synthesis / Chiral Pool Synthesis

Asymmetric aldol and related reactions, asymmetric Diels-Alder reaction, asymmetric transfer hydrogenation, asymmetric reductions, asymmetric dihydroxylation, amino hydroxylation, symmetric hydrosilylation, resolution of racemic mixture.

Carbohydrates

Our team has experience of synthesis of a wide range of carbohydrate-based compounds.

Chiral Separation

We have capability to separate chirally pure compounds via crystallization, resolution, prep HPLC purification.

Metabolites

We are experts in metabolite synthesis.

Accelerate your design-make-test
Cycle with SynSmart

Let's Start a Conversation

Tell us about your project and our experts will get back to you with the right solution.

 

Share your requirements, project goals, or specific chemistry challenges .

SynSmart Rasayan Research , Navi Mumbai, Maharashtra 400701, India

bd@synsmart.in

+91 84540 99758