Robust process development for reliable scale-up
Our expertise in developing and scaling up processes encompasses a wide range of chemical transformations and reaction chemistries.
From classical transformations to specialized chemistry, SynSmart supports your process from development through scale-up with established reaction capabilities.
- Expertise in developing and scaling up processes
- Broad portfolio of classical & specialized reactions
- High-pressure & high-temperature capabilities
Core Process Capabilities
Established capabilities across process development, scale-up and specialized reaction chemistry.
Process Development
Developing robust chemical processes across a broad range of established transformations.
Scale-Up
Scaling up developed processes using established reaction capabilities.
Broad Reaction Portfolio
Established capabilities across 20 reaction classes, from classical to specialized.
High-Pressure & High-Temperature Chemistry
Hydrogenation up to 15 bar and thermal reactions up to 200 °C.
Reaction Expertise
A broad portfolio of classical and specialized reaction chemistries, developed and scaled with precision.
Grignard Reactions
Organomagnesium (R–MgX) reagent chemistry, carried out under strict anhydrous conditions.
Reduction
Selective reductions using NaBH₄ and LiAlH₄.
Friedel–Crafts Reaction
Electrophilic aromatic alkylation and acylation using AlCl₃ or FeCl₃.
Chlorination
Chlorination using SOCl₂, POCl₃, HCl, and Cl₂.
Bromination
Bromination using bromine or HBr in acetic acid.
High-Pressure Hydrogenation
Pd/C, Pt/C, and Raney Ni at pressures up to 15 bar.
High-Temperature Reactions
Thermal reaction capabilities at temperatures up to 200 °C.
Nitration
Nitration using HNO₃ and H₂SO₄ mixed-acid systems.
Sulfonation
Sulfonation using SO₃H and oleum.
Chiral Resolutions
Established resolution chemistry for chiral compounds.
Alkylation & Acylation
Chain and acyl-group installation using R–X and R–COCl reagents.
N-BuLi, sec-BuLi & Dimethyl Zinc
Organolithium and organozinc transformations under inert, low-temperature conditions.
Amination
Amination using ammonia and primary or secondary amines.
Condensation
Aldol and Claisen-type condensation chemistry.
Oxidation
Selective, controlled oxidation reactions.
Suzuki & Heck Coupling
Established Pd-catalyzed coupling capabilities for complex synthesis.
Diazotization
Low-temperature diazotization using NaNO₂ at 0–5 °C.
Azidation
Controlled azidation chemistry using NaN₃.
Reductive & Chiral Aminations
Specialized amination methodologies, including reductive and chiral approaches.
Cyanation
Cyanation using NaCN, KCN, and CuCN.
Support Across the Reaction Spectrum
Classical Transformations
Grignard, Friedel–Crafts, nitration, sulfonation, and more.
Reduction & Hydrogenation
NaBH₄ / LiAlH₄ reduction and hydrogenation chemistry.
Coupling & Organometallic
Suzuki & Heck coupling, N-BuLi, sec-BuLi, dimethyl zinc.
Specialized Chemistry
Chiral resolutions, azidation, cyanation, and diazotization.
Our reaction expertise supports process development and scale-up across the entire reaction spectrum — from classical transformations to specialized chemistry.
Specialized Chemistry Capabilities
High-Pressure Hydrogenation
Pd/C, Pt/C, and Raney Ni at pressures up to 15 bar.
High-Temperature Reactions
Thermal reaction capabilities at temperatures up to 200 °C.
Chiral Resolutions
Established resolution chemistry for chiral compounds.
Organolithium & Organozinc Chemistry
N-BuLi, sec-BuLi, and dimethyl zinc transformations.
Suzuki & Heck Coupling
Established coupling capabilities for complex synthesis.
Reductive & Chiral Aminations
Specialized amination methodologies, including reductive and chiral approaches.
Ready to advance your process with SynSmart?
Connect with our team to discuss your process research and scale-up requirements.
Let’s Start a Conversation
Tell us about your project and our experts will get back to you with the right solution.
- Emailinfo@synsmartresearch.com
- Phone+91 22 1240 5396
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